Scopolamine butylbromide

• CAT Number: I001844
• CAS Number: 149-64-4
• Molecular Formula: C21H30BrNO4
• Molecular Weight: 440.37
• Purity: ≥95%
• Synonyms: Scopolan; Hyoscine butylbromide; N-Butylscopolammonium bromide
• Target: mAChR
• Solubility: 10 mM in water
• Storage: -20°C
• IUPAC Name: [(1S,2S,4R,5R)-9-butyl-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;bromide
• InChI: InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15?,16-,17-,18+,19-,20+,22?;/m1./s1
• InChIKey: HOZOZZFCZRXYEK-HNHWXVNLSA-M
• SMILES: CCCC[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)C.[Br-]

Scopolamine butylbromide(CAT: I001844), also known as hyoscine butyl bromide, is a competitive antagonist of muscarinic acetylcholine receptors (mAChRs). It exerts its pharmacological effects by blocking the binding of acetylcholine to the mAChRs, thereby inhibiting the actions of acetylcholine on smooth muscles, including those in the gastrointestinal tract, bladder, and uterus. Scopolamine butyl bromide is primarily used as an antispasmodic agent to relieve gastrointestinal and genitourinary spasms. It is also employed to reduce excessive salivation and respiratory secretions and to prevent motion sickness

Reference

1. Putcha L, et al. Pharmacokinetics and oral bioavailability of scopolamine in normal subjects. Pharm Res. 1989 Jun;6(6):481-5.