Scopoletin

• CAT Number: I005511
• CAS Number: 92-61-5
• Molecular Formula: C10H8O4
• Molecular Weight: 192.2
• Purity: ≥95%
• Synonyms: Esculetin 6-methyl ether;NSC 405647
• Target: NF-κB, p38 MAPK
• Solubility: DMSO ≥ 32 mg/mL
• Storage: 2-8°C
• IC50: 0.06 μM
• IUPAC Name: 7-hydroxy-6-methoxychromen-2-one
• InChI: InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3
• InChIKey: RODXRVNMMDRFIK-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C=CC(=O)O2)O

Scopolamine (Cat No.: I005511) is a compound that can be extracted from plants like Artemisia annua, which holds significant medicinal and agricultural importance. Beyond its well-known medicinal applications as a medication to alleviate nausea and motion sickness, it exhibits various agricultural biological activities. These include insecticidal and acaricidal properties, antibacterial effects, regulation of plant growth and development, and the ability to induce plant resistance against pathogens. This multifaceted compound underscores its potential value not only in human medicine but also in agriculture, where it can contribute to pest control and crop protection.

Reference

[1]. Pereira Dos Santos Nascimento MV et al. Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. 


[2]. Tabana YM et al. Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. Microvasc Res. 2016 Sep;107:17-33.