For research use only. Not for therapeutic Use.
Scriptaid（Cat No.:I002985）is a selective histone deacetylase (HDAC) inhibitor that enhances gene expression by promoting histone acetylation. By inhibiting HDAC activity, Scriptaid leads to a more open chromatin structure, allowing for increased transcription of specific genes. It is widely used in epigenetic research, particularly in studies involving gene regulation, cell differentiation, and cancer treatment. Scriptaid has been shown to induce cell cycle arrest and apoptosis in cancer cells, making it a potential therapeutic agent in oncology. Its low toxicity also makes it a valuable tool for reprogramming cells in regenerative medicine.
| Catalog Number | I002985 |
| CAS Number | 287383-59-9 |
| Synonyms | 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide |
| Molecular Formula | C₁₈H₁₈N₂O₄ |
| Purity | ≥95% |
| Target | HDAC |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IUPAC Name | 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide |
| InChI | InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21) |
| InChIKey | JTDYUFSDZATMKU-UHFFFAOYSA-N |
| SMILES | C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO |
| Reference | </br>1:Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice. Gaur V, Connor T, Venardos K, Henstridge DC, Martin SD, Swinton C, Morrison S, Aston-Mourney K, Gehrig SM, van Ewijk R, Lynch GS, Febbraio MA, Steinberg GR, Hargreaves M, Walder KR, McGee SL.Diabetes Obes Metab. 2017 Feb 2. doi: 10.1111/dom.12896. [Epub ahead of print] PMID: 28155245 </br>2:Scriptaid Upregulates Expression of Development-Related Genes, Inhibits Apoptosis, and Improves the Development of Somatic Cell Nuclear Transfer Mini-Pig Embryos. Zhang L, Huang Y, Wu Y, Si J, Huang Y, Jiang Q, Lan G, Guo Y, Jiang H.Cell Reprogram. 2017 Feb;19(1):19-26. doi: 10.1089/cell.2016.0033. Epub 2017 Jan 5. PMID: 28055234 </br>3:Effects of the histone deacetylase inhibitor /’Scriptaid/’ on the developmental competence of mouse embryos generated through round spermatid injection. Kong P, Yin M, Chen D, Li S, Li Y, Xing F, Jiang M, Fang Z, Lyu Q, Chen X.Hum Reprod. 2017 Jan;32(1):76-87. Epub 2016 Nov 17. PMID: 27864358 </br>4:Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T.Oncotarget. 2016 Nov 1;7(44):71841-71855. doi: 10.18632/oncotarget.12378. PMID: 27708247 Free PMC Article</br>5:Scriptaid Treatment Decreases DNA Methyltransferase 1 Expression by Induction of MicroRNA-152 Expression in Porcine Somatic Cell Nuclear Transfer Embryos. Liang S, Zhao MH, Choi JW, Kim NH, Cui XS.PLoS One. 2015 Aug 11;10(8):e0134567. doi: 10.1371/journal.pone.0134567. eCollection 2015. PMID: 26261994 Free PMC Article</br>6:Effects of Scriptaid on the Histone Acetylation, DNA Methylation and Development of Buffalo Somatic Cell Nuclear Transfer Embryos. Sun H, Lu F, Zhu P, Liu X, Tian M, Luo C, Ruan Q, Ruan Z, Liu Q, Jiang J, Wei Y, Shi D.Cell Reprogram. 2015 Oct;17(5):404-14. doi: 10.1089/cell.2014.0084. Epub 2015 Jun 2. PMID: 26035741 </br>7:The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells. Berghauser Pont LM, Kleijn A, Kloezeman JJ, van den Bossche W, Kaufmann JK, de Vrij J, Leenstra S, Dirven CM, Lamfers ML.PLoS One. 2015 May 18;10(5):e0127058. doi: 10.1371/journal.pone.0127058. eCollection 2015. PMID: 25993039 Free PMC Article</br>8:Effects of scriptaid on the histone acetylation of buffalo oocytes and their ability to support the development of somatic cell nuclear transfer embryos. Sun H, Lu F, Liu X, Tian M, Ruan Z, Zhu P, Ruan Q, Jiang J, Shi D.Theriogenology. 2015 Apr 15;83(7):1219-25. doi: 10.1016/j.theriogenology.2015.01.003. Epub 2015 Jan 8. PMID: 25640327 </br>9:Combination of S-adenosylhomocysteine and scriptaid, a non-toxic epigenetic modifying reagent, modulates the reprogramming of bovine somatic-cell nuclear transfer embryos. Zhang H, Wang Y, Sang Y, Zhang Y, Hua S.Mol Reprod Dev. 2014 Jan;81(1):87-97. doi: 10.1002/mrd.22287. Epub 2013 Dec 17. PMID: 24347442 </br>10:The histone deacetylase inhibitor Scriptaid improves in vitro developmental competence of ovine somatic cell nuclear transferred embryos. Wen BQ, Li J, Li JJ, Tian SJ, Sun SC, Qi X, Cai WT, Chang QL.Theriogenology. 2014 Jan 15;81(2):332-9. doi: 10.1016/j.theriogenology.2013.09.032. Epub 2013 Oct 6. PMID: 24182741 |
