SD-06

• CAT Number: I002930
• CAS Number: 271576-80-8
• Molecular Formula: C20H20ClN5O2
• Molecular Weight: 397.86
• Purity: ≥95%
• Synonyms: 1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-5-yl)piperidin-1-yl)-2-hydroxyethanone
• Target: p38
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IC50: 170 nM
• IUPAC Name: 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone
• InChI: InChI=1S/C20H20ClN5O2/c21-15-3-1-13(2-4-15)19-18(16-5-8-22-12-23-16)20(25-24-19)14-6-9-26(10-7-14)17(28)11-27/h1-5,8,12,14,27H,6-7,9-11H2,(H,24,25)
• InChIKey: CATQHDWESBRRQA-UHFFFAOYSA-N
• SMILES: C1CN(CCC1C2=C(C(=NN2)C3=CC=C(C=C3)Cl)C4=NC=NC=C4)C(=O)CO

SD 0006（Cat No.:I002930）, also known as SD-06, is an orally active and selective inhibitor of p38α MAPK. It belongs to the diaryl pyrazole class of compounds. With an IC50 value of 110 nM, it demonstrates potent inhibition of p38α MAPK by competing with ATP binding. The p38α MAPK pathway is involved in cellular signaling and plays a role in inflammation and stress responses. By selectively targeting p38α MAPK, SD 0006 shows promise as a potential therapeutic agent for conditions associated with dysregulated p38α MAPK signaling, such as inflammatory diseases and certain cancers.