SD-2590 hydrochloride

• CAT Number: I011025
• CAS Number: 226395-93-3
• Molecular Formula: C22H26ClF3N2O7S
• Molecular Weight: 554.96
• Purity: ≥95%
• Synonyms: N-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpiperidine-4-carboxamide;hydrochloride
• InChI: InChI=1S/C22H25F3N2O7S.ClH/c1-32-15-14-27-12-10-21(11-13-27,20(28)26-29)35(30,31)19-8-6-17(7-9-19)33-16-2-4-18(5-3-16)34-22(23,24)25;/h2-9,29H,10-15H2,1H3,(H,26,28);1H
• InChIKey: HJJOIVGDTLHVTK-UHFFFAOYSA-N
• SMILES: COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F.Cl

SD-2590 hydrochloride (Cat No.: I011025) is a small-molecule inhibitor that targets STAT3 (Signal Transducer and Activator of Transcription 3), a transcription factor implicated in various cancers and inflammatory diseases. By disrupting STAT3 phosphorylation and dimerization, SD-2590 inhibits its nuclear translocation and gene transcription activity, thereby reducing cell proliferation, survival, and immune evasion in tumor cells. The hydrochloride salt enhances its solubility and bioavailability for research use. It is primarily used in preclinical oncology studies to explore targeted therapies for STAT3-driven malignancies.

Reference

[1]. Becker DP, et, al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem. 2010 Sep 23;53(18):6653-80.
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