SD-36

• CAT Number: I036158
• CAS Number: 2429877-44-9
• Molecular Formula: C59H62F2N9O12P
• Molecular Weight: 1158.1666
• Purity: 98%
• Synonyms: SD36; SD 36; SD-36
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid
• InChI: InChI=1S/C59H62F2N9O12P/c60-59(61,83(80,81)82)39-21-23-43-38(31-39)32-45(63-43)54(75)65-46-34-68(51(73)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-69(57(41)78)47-26-28-50(72)66-55(47)76)30-29-40-22-25-48(70(40)58(46)79)56(77)64-44(24-27-49(62)71)53(74)67-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37/h4-5,7-10,12,14-19,21,23,31-32,40,44,46-48,52,63H,1-3,11,20,22,24-30,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t40-,44+,46+,47?,48+/m1/s1
• InChIKey: JKCSCHXVWPSGBG-OPKPGBGESA-N
• SMILES: FC(C1=CC2=C(NC(C(N[C@H]3CN(C(CCCCCC#CC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC[C@](CC[C@H]7C(N[C@@H](CCC(N)=O)C(NC(C8=CC=CC=C8)C9=CC=CC=C9)=O)=O)([H])N7C3=O)=O)=C2)C=C1)(P(O)(O)=O)F

SD-36（Cat No.:I036158） is a potent PROTAC (proteolysis-targeting chimera) that selectively degrades STAT3 protein. In both in vitro and in vivo studies, SD-36 efficiently induces the degradation of STAT3 protein. Notably, it exhibits higher selectivity for STAT3 compared to other members of the STAT family. The degradation of STAT3 by SD-36 results in significant repression of its transcriptional network in leukemia and lymphoma cells.

Reference

1. Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, Chinnaswamy K, Wen B, Dai L,Kumar P, Yang CY, Liu Z, Wang M, Liu L, Meagher JL, Yi H, Sun D, Stuckey JA, Wang S. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. J Med Chem. 2019 Dec 10. doi: 10.1021/acs.jmedchem.9b01530. [Epub ahead of print] PubMed PMID: 31747516.
2. Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, Chen J, Yang CY, Liu Z, Wang M, Liu L, Jiang H, Wen B, Kumar P, Meagher JL, Sun D, Stuckey JA, Wang S. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. doi: 10.1016/j.ccell.2019.10.002. PubMed PMID: 31715132; PubMed Central PMCID: PMC6880868.