For research use only. Not for therapeutic Use.
SD208 (Cat No.: I004365) is a selective inhibitor of transforming growth factor-beta (TGF-β) receptor I (ALK5) kinase. It has been reported to inhibit TGF-β signaling and attenuate the phosphorylation of SMAD2, a downstream effector of the TGF-β signaling pathway. SD208 has demonstrated potential in various preclinical studies for its anti-fibrotic, anti-inflammatory, and anti-tumor activities. It may have applications in the treatment of diseases associated with aberrant TGF-β signaling, such as fibrosis, cancer, and autoimmune disorders.
| Catalog Number | I004365 |
| CAS Number | 627536-09-8 |
| Synonyms | 2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine |
| Molecular Formula | C₁₇H₁₀ClFN₆ |
| Purity | ≥95% |
| Target | TGF-β Receptor |
| Solubility | DMSO >10 mg/mL |
| Storage | Store at -20°C |
| Related CAS | 1608481-61-3 (hydrochloride) |
| IC50 | 49 nM |
| IUPAC Name | 2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine |
| InChI | InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) |
| InChIKey | BERLXWPRSBJFHO-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F |
