SDZ 220-581

• CAT Number: I002276
• CAS Number: 174575-17-8
• Molecular Formula: C16H17ClNO5P
• Molecular Weight: 369.74
• Purity: ≥95%
• Synonyms: 2-amino-3-(2/’-chloro-5-(phosphonomethyl)-[1,1/’-biphenyl]-3-yl)propanoic acid
• Target: Neuronal Signaling
• Solubility: DMSO: ≤ 8.57 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2S)-2-amino-3-[3-(2-chlorophenyl)-5-(phosphonomethyl)phenyl]propanoic acid
• InChI: 1S/C16H17ClNO5P/c17-14-4-2-1-3-13(14)12-6-10(8-15(18)16(19)20)5-11(7-12)9-24(21,22)23/h1-7,15H,8-9,18H2,(H,19,20)(H2,21,22,23)/t15-/m0/s1
• InChIKey: VBRJFXSFCYEZMQ-HNNXBMFYSA-N
• SMILES: C1=CC=C(C(=C1)C2=CC(=CC(=C2)CP(=O)(O)O)C[C@@H](C(=O)O)N)Cl

SDZ 220-581 (Cat No.: I002276) is a potent and selective platelet-activating factor (PAF) receptor antagonist with strong anti-inflammatory properties. It functions by inhibiting PAF-mediated signaling pathways involved in inflammation, immune responses, and allergic reactions. SDZ 220-581 has demonstrated efficacy in preclinical models of asthma, sepsis, and other inflammatory conditions. Its high receptor affinity and specificity make it a valuable tool for studying PAF-related pathophysiology. This compound holds potential for therapeutic development in treating inflammatory and immune-mediated diseases, including respiratory and cardiovascular disorders.

Reference

[1]. Gilmour G, Broad LM, Wafford KA, In vitro characterisation of the novel positive allosteric modulators of the mGlu? receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.
[2]. Linderholm K, Powell S, Olsson E, Role of the NMDA-receptor in Prepulse Inhibition in the Rat. Int J Tryptophan Res. 2010;3:1-12.
[3]. Urwyler S, Campbell E, Fricker G, Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists–II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):655-69.
[4]. Bakshi VP, Tricklebank M, Neijt HC, Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J Pharmacol Exp Ther. 1999 Feb;288(2):643-52.