Seco Rapamycin sodium salt

• CAT Number: I001822
• CAS Number: 148554-65-8
• Molecular Formula: C51H79NO13 • Na
• Molecular Weight: 936.2
• Purity: ≥95%
• Synonyms: [2R-[2α,2(S*),3α,6β[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,7R*,19E,21R*,22(1S*,3R*,4R*)]]]-1-[oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-m
• Target: Drug Metabolite
• Solubility: DMSO: ≥ 46 mg/mL
• Storage: -20°C
• IC50: 6.45 ± 0.78 uM
• InChIKey: SETORPHJOULFMF-OWGFPTNRSA-N

Seco Rapamycin sodium salt (Cat.No:I001822) is a derivative of the immunosuppressive drug Rapamycin. It is a potent inhibitor of the mammalian target of Rapamycin (mTOR) pathway, which regulates cell growth and proliferation. Seco Rapamycin shows potential as an anticancer agent and is studied for its therapeutic applications in various cancer types.

Reference

[1]. Osmulski PA, et al. Rapamycin allosterically inhibits the proteasome. Mol Pharmacol. 2013 Jul;84(1):104-13.
[2]. Mauro-Lizcano M, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11(5):833-43.