For research use only. Not for therapeutic Use.
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].
Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis[1].
Doses (mg/kg)
Cmaxa (nmol/L)
Tmax (h)a
AUCt (uM•h)a
MRT (h)a
| Catalog Number | R047995 |
| CAS Number | 1208549-68-1 |
| Synonyms | 1-[1-(cyclopropanecarbonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea |
| Purity | ≥95% |
| InChI | InChI=1S/C17H20F3N3O3/c18-17(19,20)26-14-5-3-12(4-6-14)21-16(25)22-13-7-9-23(10-8-13)15(24)11-1-2-11/h3-6,11,13H,1-2,7-10H2,(H2,21,22,25) |
| InChIKey | CHOHWMGAQRIMFF-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)N2CCC(CC2)NC(=O)NC3=CC=C(C=C3)OC(F)(F)F |
