For research use only. Not for therapeutic Use.
SEL120-34A HCl（Cat No.:I020052）is a potent and selective inhibitor of CDK8/19 (cyclin-dependent kinase 8 and 19), key regulators of transcriptional activity in cancer cells. This compound is being investigated for its role in modulating oncogenic signaling pathways, particularly in the context of leukemia and solid tumors. By inhibiting CDK8/19, SEL120-34A HCl disrupts tumor cell proliferation and survival, making it a promising candidate in targeted cancer therapies. Its hydrochloride form enhances solubility and stability, allowing for more effective delivery in preclinical and clinical research applications.
| Catalog Number | I020052 |
| CAS Number | 1609452-30-3 |
| Molecular Formula | C₁₅H₁₈Br₂N₄.xHCl |
| Purity | ≥95% |
| Reference | [1]. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795. |
