SEL24-B489 HCl

• CAT Number: I036190
• CAS Number: 1616359-00-2
• Molecular Formula: C15H19Br2ClN4O2
• Molecular Weight: 482.14
• Purity: 98%
• Synonyms: SEL24 Hydrochloride; SEL-24 Hydrochloride; SEL 24 Hydrochloride; SEL24 HCl; SEL 24 HCl; SEL-24 HCl; SEL24B489 HCl; SEL24 B489 HCl; SEL24-B489 HCl
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: 5,6-Dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride
• InChI: InChI=1S/C15H18Br2N4O2.ClH/c1-8(2)20-11-7-10(16)12(17)14(21(22)23)13(11)19-15(20)9-3-5-18-6-4-9;/h7-9,18H,3-6H2,1-2H3;1H
• InChIKey: KQKOTVOYBRIGIT-UHFFFAOYSA-N
• SMILES: CC(N1C(C2CCNCC2)=NC3=C([N+]([O-])=O)C(Br)=C(Br)C=C31)C.[H]Cl

SEL24-B489 HCl（Cat No.:I036190） is a novel, orally available, dual PIM/FLT3 kinase inhibitor. It inhibits FLT3 wild-type and FLT3-ITD mutant kinase activities in nanomolar concentrations, leading to reduced proliferation and induction of apoptosis in acute myeloid leukemia (AML) cell lines and primary patient samples. In addition, SEL24-B489 HCl targets the PIM kinase family, which is involved in cell survival, proliferation, and drug resistance. This dual inhibition of FLT3 and PIM kinases makes SEL24-B489 HCl a promising candidate for the treatment of FLT3-mutant AML.