Selamectin

• CAT Number: R016066
• CAS Number: 220119-17-5
• Molecular Formula: C43H63NO11
• Molecular Weight: 770.00
• Purity: ≥95%
• Synonyms: Revolution; Revolution (antibiotic); Selamectin; Stronghold; (5Z)-25-Cyclohexyl-4’-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a
• Target: Membrane Transporter/Ion Channel
• Storage: -20°C
• IUPAC Name: (1R,4S,5'S,6R,6'S,8R,10E,12S,13S,14E,16E,20R,21Z,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• InChI: InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1
• InChIKey: AFJYYKSVHJGXSN-XHKIUTQPSA-N
• SMILES: C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7

Selamectin（Cat No.:R016066）is a macrocyclic lactone antiparasitic widely used in veterinary medicine for the prevention and treatment of internal and external parasites in dogs and cats. It is effective against fleas, ear mites, heartworms, sarcoptic mange, and certain intestinal worms. Selamectin works by binding to glutamate-gated chloride channels in the nervous system of parasites, causing paralysis and death. Applied topically, it is absorbed into the bloodstream and redistributed to tissues, providing prolonged protection. Its broad-spectrum efficacy and safety profile make it a popular choice for parasite management in companion animals.

Reference

1.Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. Banks B.J. Bioorg Med Chem. 2000, 8, 2017.