Selatinib

• CAT Number: I009424
• CAS Number: 1275595-86-2
• Molecular Formula: C29H26ClFN4O3S
• Molecular Weight: 565.06
• Purity: ≥95%
• Synonyms: Selatinib.;N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfinyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfinylethylamino)methyl]furan-2-yl]quinazolin-4-amine
• InChI: InChI=1S/C29H26ClFN4O3S/c1-39(36)12-11-32-16-23-7-10-27(38-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)37-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
• InChIKey: OAMVGUFHZPRXOM-UHFFFAOYSA-N
• SMILES: CS(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Selatinib(CAT: I009424) is a potent and selective small-molecule inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). It is widely used in oncology research to study signaling pathways involved in tumor growth, angiogenesis, and metastasis. By inhibiting EGFR and HER2 tyrosine kinase activity, Selatinib disrupts downstream signaling, leading to reduced tumor cell proliferation and survival. This compound is particularly valuable for investigating cancers driven by EGFR and HER2 dysregulation, such as non-small cell lung cancer (NSCLC) and breast cancer. With high specificity and stability, Selatinib supports in vitro and in vivo studies, advancing the development of targeted cancer therapies.