Selective PI3Kδ Inhibitor 1 (compound 7n)

• CAT Number: I047458
• CAS Number: 2088525-31-7
• Molecular Formula: C23H20FN7O
• Molecular Weight: 429.45
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CN1C(=NC(=N1)C2=CN=C(C(=N2)C3=CC(=C(C=C3)C(=O)N)F)N)C4(CC4)C5=CC=CC=C5

Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].

Reference

[1] Terstiege I, et al. Bioorg Med Chem Lett. 2017, 27(3):679-687.