For research use only. Not for therapeutic Use.
Selepressin is a selective vasopressin V1a receptor agonist designed to manage vasodilatory shock, particularly septic shock. By activating V1a receptors, selepressin induces vasoconstriction, increasing blood pressure and improving organ perfusion in critically ill patients. Unlike vasopressin, selepressin selectively targets V1a receptors, minimizing the risk of adverse effects associated with V2 receptor activation, such as water retention and hyponatremia. Selepressin is under investigation for its potential to improve outcomes in patients with severe septic shock, offering a more targeted therapeutic approach.
| Catalog Number | I009426 |
| CAS Number | 876296-47-8 |
| Synonyms | Selepressin; FE 202158; FE202158; FE-202158. [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin;(S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-(isopropylamino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(4-amino-4-oxobuty |
| Molecular Formula | C46H73N13O11S2 |
| Purity | ≥95% |
| Target | Vasopressin Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-5-(propan-2-ylamino)pentan-2-yl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C46H73N13O11S2/c1-5-26(4)38-45(69)54-30(14-9-17-35(48)60)41(65)56-32(21-36(49)61)42(66)57-33(24-72-71-23-28(47)39(63)55-31(43(67)58-38)20-27-12-7-6-8-13-27)46(70)59-19-11-16-34(59)44(68)53-29(15-10-18-51-25(2)3)40(64)52-22-37(50)62/h6-8,12-13,25-26,28-34,38,51H,5,9-11,14-24,47H2,1-4H3,(H2,48,60)(H2,49,61)(H2,50,62)(H,52,64)(H,53,68)(H,54,69)(H,55,63)(H,56,65)(H,57,66)(H,58,67)/t26-,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 |
| InChIKey | JCVQBJTWWDYUFQ-MRUTUVJXSA-N |
| SMILES | CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)N)C(=O)N3CCCC3C(=O)NC(CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCCC(=O)N |
