For research use only. Not for therapeutic Use.
Seletracetam (Cat.No:I009213) is an investigational antiepileptic drug that is chemically related to levetiracetam. It is under development for the treatment of epilepsy and seizure disorders. Preclinical studies indicate that seletracetam may have similar antiepileptic activity to levetiracetam but with improved pharmacokinetic properties.
| Catalog Number | I009213 |
| CAS Number | 357336-74-4 |
| Synonyms | UCB-44212; UCB44212; UCB 44212;(S)-2-((S)-4-(2,2-difluorovinyl)-2-oxopyrrolidin-1-yl)butanamide |
| Molecular Formula | C10H14F2N2O2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide |
| InChI | InChI=1S/C10H14F2N2O2/c1-2-7(10(13)16)14-5-6(3-8(11)12)4-9(14)15/h3,6-7H,2,4-5H2,1H3,(H2,13,16)/t6-,7+/m1/s1 |
| InChIKey | ANWPENAPCIFDSZ-RQJHMYQMSA-N |
| SMILES | CCC(C(=O)N)N1CC(CC1=O)C=C(F)F |
| Reference | </br>1:Seletracetam enhances short term depression in vitro. Yang X, Meehan AL, Rothman SM, Dubinsky JM.Epilepsy Res. 2015 Nov;117:17-22. doi: 10.1016/j.eplepsyres.2015.08.006. Epub 2015 Aug 8. PMID: 26320080 </br>2:Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy. Matagne A, Margineanu DG, Potschka H, Löscher W, Michel P, Kenda B, Klitgaard H.Eur J Pharmacol. 2009 Jul 1;614(1-3):30-7. doi: 10.1016/j.ejphar.2009.04.024. Epub 2009 Apr 19. PMID: 19383493 </br>3:Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Martella G, Bonsi P, Sciamanna G, Platania P, Madeo G, Tassone A, Cuomo D, Pisani A.Epilepsia. 2009 Apr;50(4):702-10. doi: 10.1111/j.1528-1167.2008.01915.x. Epub 2008 Dec 4. PMID: 19055493 Free Article</br>4:Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster. Hamann M, Sander SE, Richter A.Eur J Pharmacol. 2008 Dec 28;601(1-3):99-102. doi: 10.1016/j.ejphar.2008.10.048. Epub 2008 Nov 6. PMID: 19014930 </br>5:Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Pollard JR.Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. Review. PMID: 18183537 </br>6:Seletracetam (UCB 44212). Bennett B, Matagne A, Michel P, Leonard M, Cornet M, Meeus MA, Toublanc N.Neurotherapeutics. 2007 Jan;4(1):117-22. Review. PMID: 17199025 |
