For research use only. Not for therapeutic Use.
Seliforant (SENS-111) is a selective and orally histamine H4 receptor antagonist.
| Catalog Number | I036198 |
| CAS Number | 1164115-89-2 |
| Synonyms | 6-[3-(methylamino)azetidin-1-yl]-2-(2-methylpropyl)pyrimidin-4-amine |
| Molecular Formula | C12H21N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H21N5/c1-8(2)4-11-15-10(13)5-12(16-11)17-6-9(7-17)14-3/h5,8-9,14H,4,6-7H2,1-3H3,(H2,13,15,16) |
| InChIKey | QRBVUFXEMHNIDB-UHFFFAOYSA-N |
| SMILES | CC(C)CC1=NC(=CC(=N1)N2CC(C2)NC)N |
| Reference | [1]. Petremann M, Gueguen C, Delgado Betancourt V, Wersinger E, Dyhrfjeld-Johnsen J. Effect of the novel histamine H4 receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss. Br J Pharmacol. 2020;177(3):623-633. [2]. Venail F, Attali P, Wersinger E, Gomeni R, Poli S, Schmerber S. Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects. Br J Clin P |
