For research use only. Not for therapeutic Use.
Senexin A（Cat No.:I009436）is a selective inhibitor of cyclin-dependent kinase 8 (CDK8), an enzyme involved in transcriptional regulation and various cellular processes. By inhibiting CDK8, Senexin A modulates gene expression and impacts pathways associated with inflammation, cancer progression, and stem cell biology. This compound is particularly valuable for researchers studying the role of CDK8 in cancer biology, as it can reduce tumor cell growth and alter oncogenic signaling pathways. Its specificity and efficacy make Senexin A a powerful tool for exploring targeted cancer therapies and transcriptional regulation mechanisms.
| Catalog Number | I009436 |
| CAS Number | 1366002-50-7 |
| Synonyms | Senexin A;4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitril |
| Molecular Formula | C17H14N4 |
| Purity | ≥95% |
| Target | CDK8/19 inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IC50 | 280 nM |
| IUPAC Name | 4-(2-phenylethylamino)quinazoline-6-carbonitrile |
| InChI | InChI=1S/C17H14N4/c18-11-14-6-7-16-15(10-14)17(21-12-20-16)19-9-8-13-4-2-1-3-5-13/h1-7,10,12H,8-9H2,(H,19,20,21) |
| InChIKey | XBJCNHGQFJFCOY-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCNC2=NC=NC3=C2C=C(C=C3)C#N |
| Reference | </br>Mengqian Chen, Martina McDermott, Zhengguan Yang, Jiaxin Liang, Gary P. Schools, Chang-uk Lim, Tao Lu, Stark R. George, Deborah K. West, Donald C. Porter, Eugenia V. Broude, Igor B. Roninson. CDK8: A new druggable mediator of NFκB activity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4883. doi:10.1158/1538-7445.AM2014-4883 |
