For research use only. Not for therapeutic Use.
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement[1].
SENP1-IN-1 may improve the sensitivity of tumor cells to irradiation[1].
SENP1-IN-1 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1].
| Catalog Number | I044562 |
| CAS Number | 2416910-69-3 |
| Synonyms | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-N-[2-[2-hydroxyethyl(methyl)amino]-2-oxoethyl]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxamide |
| Molecular Formula | C35H58N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H58N2O4/c1-22-11-16-35(30(41)36-21-28(40)37(8)19-20-38)18-17-33(6)24(29(35)23(22)2)9-10-26-32(5)14-13-27(39)31(3,4)25(32)12-15-34(26,33)7/h9,22-23,25-27,29,38-39H,10-21H2,1-8H3,(H,36,41)/t22-,23+,25+,26-,27+,29+,32+,33-,34-,35+/m1/s1 |
| InChIKey | GYEWLVQWUVDKKH-SKHUFZRLSA-N |
| SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)NCC(=O)N(C)CCO |
| Reference | [1]. Li, Yiliang, et al. Preparation of ursolic acid derivatives useful as SENP1 inhibitors and tumor radiosensitizer. CN110627860A. |
