Seocalcitol

• CAT Number: I001312
• CAS Number: 134404-52-7
• Molecular Formula: C30H46O3
• Molecular Weight: 454.71
• Purity: ≥95%
• Synonyms: (1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-1-[(2R,3E,5E)-7-ethyl-7-hydroxynona-3,5-dien-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• Target: VD/VDR
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IUPAC Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3E,5E)-7-ethyl-7-hydroxynona-3,5-dien-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• InChI: InChI=1S/C30H46O3/c1-6-30(33,7-2)18-9-8-11-21(3)26-15-16-27-23(12-10-17-29(26,27)5)13-14-24-19-25(31)20-28(32)22(24)4/h8-9,11,13-14,18,21,25-28,31-33H,4,6-7,10,12,15-17,19-20H2,1-3,5H3/b11-8+,18-9+,23-13+,24-14-/t21-,25-,26-,27+,28+,29-/m1/s1
• InChIKey: LVLLALCJVJNGQQ-SEODYNFXSA-N
• SMILES: CCC(CC)(/C=C/C=C/[C@@H](C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C)O

Seocalcitol(CAT: I001312) is a vitamin D3 analog with potent anti-proliferative and pro-differentiation properties. It modulates the vitamin D receptor (VDR), influencing gene expression pathways critical for cell cycle regulation and apoptosis. Seocalcitol is particularly valuable in oncology research, supporting studies on its therapeutic potential in cancer treatment, especially in conditions like hepatocellular carcinoma and other solid tumors. Its targeted mechanism provides insights into the role of VDR modulation in tumor suppression. Seocalcitol is a vital tool for advancing research into vitamin D analogs and their applications in cancer therapy and drug development.