For research use only. Not for therapeutic Use.
Serlopitant(cas 860642-69-9), also known as VPD-737, is a drug which acts as an NK1 receptor antagonist. It is currently under phase II clinical trials for the treatment of Pruritus. <span></span>
Catalog Number | I009441 |
CAS Number | 860642-69-9 |
Synonyms | VPD-737; VPD737; VPD 737; MK-0594; MK 0594; MK0594; Serlopitant.;3-((3aR,4R,5S,7aS)-5-((1R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-4-(4 fluorophenyl)octahydro-2H-isoindol-2-yl)cyclopent-2-en-1-one |
Molecular Formula | C29H28F7NO2 |
Purity | ≥95% |
Target | NK1 receptor antagonist |
Solubility | Soluble in DMSO, not in water |
Storage | 0 - 4 °C for short term, or -20 °C for long term |
Overview of Clinical Research | Originator: Merck & Co<br /> |
IUPAC Name | 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one |
InChI | InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1 |
InChIKey | FLNYCRJBCNNHRH-OIYLJQICSA-N |
SMILES | CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2CCC3CN(CC3C2C4=CC=C(C=C4)F)C5=CC(=O)CC5 |