Serlopitant

For research use only. Not for therapeutic Use.

  • CAT Number: I009441
  • CAS Number: 860642-69-9
  • Molecular Formula: C29H28F7NO2
  • Molecular Weight: 555.537
  • Purity: ≥95%
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Serlopitant(cas 860642-69-9), also known as&nbsp;VPD-737,&nbsp;is a drug which acts as an NK1 receptor antagonist.&nbsp;It is currently under phase II clinical trials for the treatment of Pruritus.&nbsp;<span></span>


Catalog Number I009441
CAS Number 860642-69-9
Synonyms

VPD-737; VPD737; VPD 737; MK-0594; MK 0594; MK0594; Serlopitant.;3-((3aR,4R,5S,7aS)-5-((1R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-4-(4 fluorophenyl)octahydro-2H-isoindol-2-yl)cyclopent-2-en-1-one

Molecular Formula C29H28F7NO2
Purity ≥95%
Target NK1 receptor antagonist
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
Overview of Clinical Research

Originator: Merck &amp; Co<br />
Developer: Epidermolysis Bullosa Research Partnership; Menlo Therapeutics; Merck &amp; Co; Stanford University; Velocity Pharmaceutical Development<br />
Class: Antipruritics; Cyclopentanes; Isoindoles; Skin disorder therapies; Small molecules; Urologics<br />
Mechanism of Action: Neurokinin 1 receptor antagonists<br />
Orphan Drug Status: No<br />
New Molecular Entity: Yes<br />

IUPAC Name 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one
InChI InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1
InChIKey FLNYCRJBCNNHRH-OIYLJQICSA-N
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2CCC3CN(CC3C2C4=CC=C(C=C4)F)C5=CC(=O)CC5

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