For research use only. Not for therapeutic Use.
Setastine HCl(CAT: I036244) is a potent antagonist of histamine H1 receptors. Histamine H1 receptors are G protein-coupled receptors that mediate various physiological responses to histamine, including allergic reactions and inflammation. By blocking the H1 receptors, setastine HCl inhibits the binding of histamine to these receptors, thereby preventing or reducing the histamine-induced responses. Setastine HCl is commonly used as an antihistamine medication to alleviate symptoms associated with allergies, such as sneezing, itching, and nasal congestion. Its antagonistic activity on H1 receptors makes it an effective treatment option for allergic conditions.
| Catalog Number | I036244 |
| CAS Number | 59767-13-4 |
| Synonyms | Setastine hydrochloride; Setastine HCl; EGYT-2062; EGYT 2062; EGYT2062; Loderix; |
| Molecular Formula | C22H29Cl2NO |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)azepane hydrochloride |
| InChI | InChI=1S/C22H28ClNO.ClH/c1-22(19-9-5-4-6-10-19,20-11-13-21(23)14-12-20)25-18-17-24-15-7-2-3-8-16-24;/h4-6,9-14H,2-3,7-8,15-18H2,1H3;1H |
| InChIKey | YFCVXQAEHQJKQG-UHFFFAOYSA-N |
| SMILES | CC(OCCN1CCCCCC1)(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.[H]Cl |
| Reference | 1: Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L. Pharmacology of the new H1-receptor antagonist setastine hydrochloride. Arzneimittelforschung. 1990 Dec;40(12):1340-5. PubMed PMID: 1982751. |
