For research use only. Not for therapeutic Use.
Setiptiline maleate (Cat No.: I005139) is a tetracyclic antidepressant that functions as a noradrenergic and specific serotonergic antidepressant (NaSSA). It acts primarily by antagonizing central presynaptic α2-adrenergic receptors and certain serotonin receptors (5-HT2 and 5-HT3), enhancing norepinephrine and serotonin neurotransmission. Setiptiline also exhibits antihistaminic activity, contributing to its sedative effects. It has been used in the treatment of depression, particularly when accompanied by anxiety or insomnia. Its unique pharmacological profile makes it useful in neuropsychiatric research and mood disorder therapies.
| CAS Number | 85650-57-3 |
| Synonyms | 2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine maleate |
| Molecular Formula | C23H23NO4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (Z)-but-2-enedioic acid;4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene |
| InChI | 1S/C19H19N.C4H4O4/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20;5-3(6)1-2-4(7)8/h2-9H,10-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | AVPIBVPBCWBXIU-BTJKTKAUSA-N |
| SMILES | CN1CCC2=C(C1)C3=CC=CC=C3CC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O |
| Reference | <p style=/line-height:25px/> <br>[3]. Kuniyoshi M, Nakamura J, Miura C, Inanaga K. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46. <br>[4]. Niho T, Ito C, Shibutani Y, Hashizume H, Yamaguchi K. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88(4):309-20. <br>[5]. Setiptiline </p> |
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