Sevelamer Carbonate

• CAT Number: A000485
• CAS Number: 845273-93-0
• Molecular Formula: C7H14ClNO4
• Molecular Weight: 211.642
• Purity: ≥95%
• Storage: 3 years -20C powder
• IUPAC Name: carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine
• InChI: InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
• InChIKey: PADGNZFOVSZIKZ-UHFFFAOYSA-N
• SMILES: C=CCN.C1C(O1)CCl.C(=O)(O)O

Sevelamer carbonate (CAS 845273-93-0) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
Sevelamer carbonate is designed as an alternative to sevelamer hydrochloride with enhanced buffering capacity. The sevelamer moiety consists of a carbon backbone with multiple amine groups, each separated from the backbone by a single carbon atom. In the intestine, Sevelamer carbonate become protonated and subsequently bind to dietary phosphorus molecules via ionic and hydrogen interactions. The result of these interactions is a decrease in phosphorus levels within the gastrointestinal tract, resulting in decreased dietary phosphorus absorption and decreased serum phosphorus levels. In addition to the effect on phosphorus levels, the polymeric amine structure of sevelamer has been shown to bind bile acids to reduces total cholesterol levels.Sevelamer Carbonate is able to reduce renal failure triggered inflammation and induced endotoxemia in experimental model of chronic kidney disease.

Reference

1.Delmez, J., et al. "A randomized, double-blind, crossover design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis." Clinical nephrology 68.6 (2007): 386.
2.Barna, Mary M., Toros Kapoian, and Neeta Bahal O'Mara. "Sevelamer carbonate." Annals of Pharmacotherapy 44.1 (2010): 127-134.
3.Hauser, Aline B., et al. "Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of uremia." Blood purification 30.3 (2010): 153-158.