For research use only. Not for therapeutic Use.
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].
SF2312 is selectively toxic to ENO1-deleted glioma cells. SF2312 inhibits the proliferation (2 weeks treatment course) of the ENO1-deleted D423 glioma cell line in the low μM range whist isogenically ENO1-rescued D423 cells, ectopically re-expressing ENO1 only shows inhibition of proliferation at concentrations of SF2312 above 200 μM. SF2312 (10 μM) dose-dependently reduces the conversion of U-13C glucose to 13C lactate in a manner selective for ENO1-deleted over ENO1-rescued or otherwise ENO1-intact glioma cells[1].
SF2312 is produced by the actinomycete Micromonospora and is active against a range of bacteria, with strong activity against Salmonella and Staphylococcus, weak activity against E. coli, and no activity against fungi[1].
| Catalog Number | I036257 |
| CAS Number | 107729-45-3 |
| Synonyms | (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid |
| Molecular Formula | C4H8NO6P |
| Purity | ≥95% |
| InChI | InChI=1S/C4H8NO6P/c6-3-1-2(12(9,10)11)4(7)5(3)8/h2-3,6,8H,1H2,(H2,9,10,11) |
| InChIKey | CGWBGDOPBYWJKZ-UHFFFAOYSA-N |
| SMILES | C1C(C(=O)N(C1O)O)P(=O)(O)O |
| Reference | [1]. Paul G Leonard, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058. |
