For research use only. Not for therapeutic Use.
SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1].
SG-094 (72 hours) shows antiproliferative effects against RIL175 cells, with an IC50 of 3.7 μM[1].
SG-094 (10 μM) blocks PI(3,5)P2-elicited TPC2 currents on isolated endolysosomes from HEK293 cells expressing TPC2-EGFP[1].
SG-094 (10 μM; pretreated for 1 h) significantly reduces VEGF-induced phosphorylation of eNOS, JNK, MAPK, and AKT without decreasing their total protein levels in HUVECs[1].
SG-094 (1-5 μM; pretreated for 1 h) increases OCR/ECAR ratios of RIL175 WT cells after glucose starvation[1].
SG-094 (90 nmol/kg; every 2-3 days over a 10-day timescale) inhibits hepatocellular carcinoma (HCC) tumor growth in mice[1].
| Catalog Number | I042061 |
| CAS Number | 2922283-37-0 |
| Synonyms | 6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline |
| Molecular Formula | C30H29NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H29NO3/c1-31-18-17-23-20-29(32-2)30(34-25-11-7-4-8-12-25)21-27(23)28(31)19-22-13-15-26(16-14-22)33-24-9-5-3-6-10-24/h3-16,20-21,28H,17-19H2,1-2H3 |
| InChIKey | BTNHPUSFPKFAPU-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=CC=CC=C4)OC5=CC=CC=C5)OC |
| Reference | [1]. Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. |
