For research use only, not for therapeutic use.
SGC-CK2-1 (Cat No.:I036276) is a potent and selective inhibitor of the protein kinase CK2 (Casein Kinase 2). CK2 is a serine/threonine kinase that regulates various cellular processes, including cell growth, proliferation, and survival. SGC-CK2-1 has been developed as a research tool to investigate the role of CK2 in cellular signaling pathways and to explore its potential as a therapeutic target in diseases such as cancer and neurodegenerative disorders. By selectively inhibiting CK2 activity, SGC-CK2-1 may modulate the dysregulated signaling pathways associated with these diseases and provide insights into the development of novel therapeutic strategies.
| Catalog Number | I036276 |
| CAS Number | 2470424-39-4 |
| Synonyms | SGC-CK2-1; SGCCK2-1; SGC CK2-1; SGC-CK21; SGC-CK2-1; SGC-CK2 1; |
| Molecular Formula | C21H22N6O |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide |
| InChI | InChI=1S/C20H21N7O/c1-3-19(28)25-16-8-15(5-4-12(16)2)23-17-9-18(24-14-6-7-14)27-20(26-17)13(10-21)11-22-27/h4-5,8-9,11,14,24H,3,6-7H2,1-2H3,(H,23,26)(H,25,28) |
| InChIKey | YKDZIFFKQUNVHH-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1=C(C=CC(=C1)NC2=NC3=C(C=NN3C(=C2)NC4CC4)C#N)C |
| Reference | 1: Licciardello MP, Workman P. A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 May;42(5):313-315. doi: 10.1016/j.tips.2021.02.002. Epub 2021 Mar 23. PMID: 33771354. |
