SGC-STK17B-1

• CAT Number: I047668
• CAS Number: 2650530-00-8
• Molecular Formula: C16H10N2O2S3
• Molecular Weight: 358.46
• Purity: ≥95%
• IUPAC Name: 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
• InChI: InChI=1S/C16H10N2O2S3/c19-14(20)7-21-16-15-10(17-8-18-16)6-13(23-15)12-5-9-3-1-2-4-11(9)22-12/h1-6,8H,7H2,(H,19,20)
• SMILES: C1=CC=C2C(=C1)C=C(S2)C3=CC4=C(S3)C(=NC=N4)SCC(=O)O

SGC-STK17B-1 is a potent, selective and ATP-competitive STK17B inhibitor with an IC50 value of 43 nM.
KEYWORDS: SGC-STK17B-1 | Supplier | STK17B inhibitor | CAS [2650530-00-8] | AKT/GSK-3β/Snail signaling | STK17 | Inhibitor | Enzymes | DRAK2 | DAPK | Hepatocellular carcinoma | Breast cancer | Autoimmunity | Dark kinase

Reference

A Picado et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63(23):14626-14646.