SGC2085

• CAT Number: R067043
• CAS Number: 1821908-49-9
• Molecular Formula: C19H24N2O2.HCl
• Molecular Weight: 348.87
• Purity: ≥95%
• IUPAC Name: (2S)-2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]propanamide;hydrochloride
• InChI: InChI=1S/C19H24N2O2.ClH/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20;/h5-10,15H,11,20H2,1-4H3,(H,21,22);1H/t15-;/m0./s1
• SMILES: CC1=CC(=CC(=C1)OC2=C(C=C(C=C2)CNC(=O)[C@H](C)N)C)C.Cl

Potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1 or PRMT4) inhibitor (IC50 value 50 nM and >100-fold selectivity over other PRMTs). Unfortunately, no cellular activity was observed for SGC2085 when tested up to 10 μM due to due to poor cell permeability (in HEK293 cells).
KEYWORDS: SGC2085 | supplier | CARM1 inhibitor | SGC-2085 | CAS [1821908-49-9] | [1821908-48-8] | Arginine | PRMT4 | Coactivator Associated Arginine Methyltransferase 1 | oncology | Wnt | β-Catenin

Reference

R Ferreira de Freitas et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47.