SGC707

• CAT Number: I002204
• CAS Number: 1687736-54-4
• Molecular Formula: C16H18N4O2
• Molecular Weight: 298.34
• Purity: ≥95%
• Synonyms: 1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
• Target: Histone Methyltransferase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 31 nM
• IUPAC Name: 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
• InChI: 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
• InChIKey: DMIDPTCQPIJYFE-UHFFFAOYSA-N
• SMILES: C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3

SGC707 (Cat No.: I002204) is a potent, selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3), an enzyme involved in post-translational modification of proteins. By inhibiting PRMT3, SGC707 modulates arginine methylation, impacting gene expression, RNA processing, and cellular signaling. It exhibits high specificity without significantly affecting other PRMT family members, making it a valuable chemical probe for studying PRMT3 function in epigenetics and disease contexts. SGC707 is widely used in research to explore the therapeutic potential of targeting PRMT3 in cancer and metabolic disorders.

Reference

[1]. Kaniskan H?, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.