SH-053-R-CH3-2’F

• CAT Number: I012229
• CAS Number: 872874-14-1
• Molecular Formula: C23H18FN3O2
• Molecular Weight: 387.414
• Purity: ≥95%
• Synonyms: (4R)-8-Ethynyl-6-(2-fluorophenyl)-4-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• IUPAC Name: ethyl (4R)-8-ethynyl-6-(2-fluorophenyl)-4-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• InChI: InChI=1S/C23H18FN3O2/c1-4-15-10-11-19-17(12-15)20(16-8-6-7-9-18(16)24)26-14(3)22-21(23(28)29-5-2)25-13-27(19)22/h1,6-14H,5H2,2-3H3/t14-/m1/s1
• InChIKey: NGYKELBMVXBFSM-CQSZACIVSA-N
• SMILES: CCOC(=O)C1=C2C(N=C(C3=C(N2C=N1)C=CC(=C3)C#C)C4=CC=CC=C4F)C

SH-053-R-CH3-2’F is a synthetic compound that functions as a positive allosteric modulator (PAM) of the GABA-A receptor, specifically targeting the benzodiazepine site. It is part of a class of compounds studied for their potential to enhance the effects of GABA, the primary inhibitory neurotransmitter in the brain, without the full sedative or addictive properties associated with traditional benzodiazepines. SH-053-R-CH3-2’F has shown promise in preclinical studies for its anxiolytic and anticonvulsant effects, making it a candidate for developing new treatments for anxiety disorders, epilepsy, and other conditions involving dysregulated GABAergic signaling.