For research use only. Not for therapeutic Use.
| Catalog Number | I009455 |
| CAS Number | 701976-54-7 |
| Synonyms | SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II.;(R)-2-methoxy-3-(octadecyloxy)propyl ((1S,2R,3S,4R,6R)-2,3,4-trihydroxy-6-methoxycyclohexyl) hydrogen phosphate |
| Molecular Formula | C₂₈H₅₇O₉P |
| Purity | ≥95% |
| Target | AKT inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C28H57O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-35-22-24(34-2)23-36-38(32,33)37-26-20-19-25(29)27(30)28(26)31/h24-31H,3-23H2,1-2H3,(H,32,33)/t24-,25?,26?,27?,28?/m1/s1 |
| InChIKey | XSYODYDCSYFRRB-KTTODTSBSA-N |
| SMILES | CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC1CCC(C(C1O)O)O)OC |
| Reference | </br>1:Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations. Krech T, Thiede M, Hilgenberg E, Schäfer R, Jürchott K.BMC Cancer. 2010 Jun 14;10:287. doi: 10.1186/1471-2407-10-287. PMID: 20546605 Free PMC Article</br>2:[Surfactant production by the Rhodococcus erythropolis sH-5 bacterium grown on various carbon sources]. Gogotov IN, Khodakov RS.Prikl Biokhim Mikrobiol. 2008 Mar-Apr;44(2):207-12. Russian. PMID: 18669264 </br>3:SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Sethi G, Ahn KS, Sung B, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB.Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. doi: 10.1016/j.bcp.2008.05.023. Epub 2008 Jul 5. PMID: 18606397 |
