Shikonin (CAT: I003868) is a naturally occurring naphthoquinone compound derived from the roots of the plant Lithospermum erythrorhizon. It possesses various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Shikonin has been traditionally used in traditional Chinese medicine for its wound healing and anti-inflammatory effects. It has shown promising potential as an anticancer agent, exhibiting inhibitory effects on various cancer cell lines and tumor growth. Shikonin’s mechanism of action involves the modulation of multiple signaling pathways, including apoptosis, cell cycle regulation, and inflammation. Furthermore, it has been investigated for its potential therapeutic applications in dermatological disorders and microbial infections.
| Catalog Number | I003868 |
| CAS Number | 517-89-5 |
| Synonyms | C.I. 75535;Isoarnebin 4;NSC 252844 |
| Molecular Formula | C₁₆H₁₆O₅ |
| Purity | ≥95% |
| Target | target: TMEM16A chloride channel [1] |
| Solubility | DMSO ≥ 31 mg/mL |
| Storage | -20°C |
| InChI | InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3 |
| InChIKey | NEZONWMXZKDMKF-UHFFFAOYSA-N |
| SMILES | CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C |
| Reference | <p style=/line-height:25px/> <br>[2]. Fu D et al. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med. 2016 Oct;12(4):2735-2740. <br>[3]. Zorman J et al. Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. PLoS One. 2016 Jul 28 </p> |
