For research use only. Not for therapeutic Use.
(-)SHIN2（Cat No.:I041426）is a potent, selective inhibitor of the transcription factor STAT3 (Signal Transducer and Activator of Transcription 3), which plays a critical role in immune response, cell survival, and oncogenesis. By blocking STAT3 activation, (-)SHIN2 has the potential to suppress tumor growth and metastasis, making it a promising candidate for cancer therapy. It has shown effectiveness in preclinical models of various cancers, including breast, lung, and colon cancer. Ongoing research is focused on evaluating its pharmacological properties, safety, and efficacy, with a particular interest in combination therapies for cancer treatment.
| Synonyms | (4R)-6-amino-4-[3-(hydroxymethyl)-5-(5-hydroxypent-1-ynyl)phenyl]-3-methyl-4-propan-2-yl-2H-pyrano[2,3-c]pyrazole-5-carbonitrile |
| Molecular Formula | C23H26N4O3 |
| Purity | ≥95% |
| IUPAC Name | (4R)-6-amino-4-[3-(hydroxymethyl)-5-(5-hydroxypent-1-ynyl)phenyl]-3-methyl-4-propan-2-yl-2H-pyrano[2,3-c]pyrazole-5-carbonitrile |
| InChI | InChI=1S/C23H26N4O3/c1-14(2)23(19(12-24)21(25)30-22-20(23)15(3)26-27-22)18-10-16(7-5-4-6-8-28)9-17(11-18)13-29/h9-11,14,28-29H,4,6,8,13,25H2,1-3H3,(H,26,27)/t23-/m1/s1 |
| InChIKey | IWUCUJZMKDHLOF-HSZRJFAPSA-N |
| SMILES | CC1=C2C(=NN1)OC(=C([C@]2(C3=CC(=CC(=C3)C#CCCCO)CO)C(C)C)C#N)N |
