SHIP2-IN-1

• CAT Number: I019352
• CAS Number: 2252247-80-4
• Molecular Formula: C17H13Cl2FN4O
• Molecular Weight: 379.22
• Purity: ≥95%
• Synonyms: 5-[5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]pyrimidin-2-amine
• InChI: InChI=1S/C17H13Cl2FN4O/c1-9(15-13(18)2-3-14(20)16(15)19)25-12-4-10(5-22-8-12)11-6-23-17(21)24-7-11/h2-9H,1H3,(H2,21,23,24)/t9-/m1/s1
• InChIKey: ATPYDXUUBCDYKQ-SECBINFHSA-N
• SMILES: CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].

Reference

[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer’s disease. Eur J Med Chem. 2018 Sep 5;157:405-422.
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