SHMT-IN-2（Cat No.:I043470）is a selective inhibitor of serine hydroxymethyltransferase (SHMT), an enzyme involved in one-carbon metabolism, which plays a crucial role in DNA synthesis, repair, and methylation. SHMT is important for cellular processes such as cell division and the production of nucleotides. By inhibiting SHMT, SHMT-IN-2 disrupts these essential metabolic pathways, leading to impaired cell growth and proliferation. This compound is being studied for its potential therapeutic applications in cancer, where rapidly dividing cells are dependent on SHMT activity, offering a novel approach to cancer treatment by targeting metabolic vulnerabilities.