For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>SHP099 is a selective and orally bioavailable small-molecule SHP2 inhibitor with IC50 of 0.071 μM.<br>target: SHP2<br>IC 50: 0.071 μM<br>In vitro:SHP099 concurrently binds to the interface of the N-terminal SH2, C-terminal SH2, and protein tyrosine phosphatase domains, thus inhibiting SHP2 activity through an allostericmechanism. SHP099 suppresses RAS-ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells [1]<br>In vivo: 1) SHP2 knockdown inhibits the growth of established KYSE520 xenograft tumours.2) plasma SHP099 concentration and xenograft p-ERK levels following a single oral administration of SHP099 (100 mg per kg)<br></p>
Catalog Number | I002342 |
CAS Number | 1801747-42-1 |
Synonyms | 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine |
Molecular Formula | C16H19Cl2N5 |
Purity | ≥95% |
Target | Metabolic Enzyme/Protease |
Solubility | DMSO: ≤ 6.4 mg/mL (Need ultrasonic) |
Storage | -20°C |
InChIKey | YGUFCDOEKKVKJK-UHFFFAOYSA-N |
Reference | <p style=/line-height:25px/> |