For research use only. Not for therapeutic Use.
SHR0302 (Cat No.:I015377) is a potent and orally active inhibitor of the Janus kinase (JAK) family, with a particular affinity for JAK1. It exhibits selectivity for JAK1 over JAK2, JAK3, and Tyk2. By inhibiting JAK1-STAT3 phosphorylation, SHR0302 exerts anti-proliferative and anti-inflammatory effects. In hepatic stellate cells (HSCs), SHR0302 inhibits their proliferation, activation, and migration in a concentration-dependent manner. It induces apoptosis in HSCs by activating caspase-3 and Bax while reducing the expression of Bcl-2. SHR0302 also inhibits the Akt signaling pathway. In animal models, SHR0302 demonstrates efficacy in attenuating the severity of experimental arthritis and reducing inflammatory markers.
| Catalog Number | I015377 |
| CAS Number | 1445987-21-2 |
| Molecular Formula | C₁₈H₂₂N₈O₂S |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| IUPAC Name | (3aS,6aR)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxamide |
| InChI | InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12? |
| InChIKey | DNBCBAXDWNDRNO-FOSCPWQOSA-N |
| SMILES | CN(C1C[C@@H]2CN(C[C@@H]2C1)C(=O)NC3=NC(=NS3)OC)C4=NC=NC5=C4C=CN5 |
| Reference | [1]. Huaxun Wu, et al. JAK1-STAT3 Blockade by JAK Inhibitor SHR0302 Attenuates Inflammatory Responses of Adjuvant-Induced Arthritis Rats and Decreases Th17 and Total B Cells. Joint Bone Spine. 2016 Oct;83(5):525-32.<br>[2]. Yuan-Jing Gu, et al. Targeted Blockade of JAK/STAT3 Signaling Inhibits Proliferation, Migration and Collagen Production as Well as Inducing the Apoptosis of Hepatic Stellate Cells. Int J Mol Med. 2016 Sep;38(3):903-11. |
