Shz-1

• CAT Number: R021930
• CAS Number: 326886-05-9
• Molecular Formula: C13H11BrN2O3S
• Molecular Weight: 355.21
• Purity: ≥95%
• Synonyms: N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide
• InChI: InChI=1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+
• InChIKey: OEMCLQLAWYKPRK-OQLLNIDSSA-N
• SMILES: C1=CC=C(C=C1)S(=O)(=O)N/N=C/C2=C(C=CC(=C2)Br)O

Shz-1（Cat No.:R021930）is a selective small molecule inhibitor that targets the SHH (Sonic Hedgehog) signaling pathway, which plays a crucial role in cell growth, differentiation, and tissue patterning. This pathway is often dysregulated in various cancers, including basal cell carcinoma and medulloblastoma. Shz-1 has shown promise in preclinical studies by inhibiting the aberrant activation of SHH signaling, potentially leading to the suppression of tumor growth. Further clinical research is necessary to assess its therapeutic potential, safety, and efficacy in treating SHH-related cancers and other disorders linked to this signaling pathway.