Shz-1

• CAT Number: R021930
• CAS Number: 326886-05-9
• Molecular Formula: C13H11BrN2O3S
• Molecular Weight: 355.21
• Purity: ≥95%
• Synonyms: N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide
• InChI: InChI=1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+
• InChIKey: OEMCLQLAWYKPRK-OQLLNIDSSA-N
• SMILES: C1=CC=C(C=C1)S(=O)(=O)NN=CC2=C(C=CC(=C2)Br)O

Shz-1, a small cardiogenic molecule, induces various cardiac-specific genes including sarcomeric tropomyosin in P19CL6 cells. Shz-1 induces Nkx2.5 expression in mouse. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells[1].

Reference

[1]. Changlong Nan, et al. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule. Cardiovasc Toxicol. 2015 Jan;15(1):29-40.
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