For research use only. Not for therapeutic Use.
SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].
SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells[1].
SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines[1].
SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells[2].
| Catalog Number | I041199 |
| CAS Number | 1392816-46-4 |
| Synonyms | 2-[[1-[(E)-2-phenylethenyl]-4-(2-phenylethylamino)pyrazolo[3,4-d]pyrimidin-6-yl]amino]ethanol |
| Molecular Formula | C23H24N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C23H24N6O/c30-16-14-25-23-27-21(24-13-11-18-7-3-1-4-8-18)20-17-26-29(22(20)28-23)15-12-19-9-5-2-6-10-19/h1-10,12,15,17,30H,11,13-14,16H2,(H2,24,25,27,28)/b15-12+ |
| InChIKey | LAOYAWHHLUVMFT-NTCAYCPXSA-N |
| SMILES | C1=CC=C(C=C1)CCNC2=C3C=NN(C3=NC(=N2)NCCO)C=CC4=CC=CC=C4 |
| Reference | [1]. Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. [2]. Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. |
