SIBA

• CAT Number: I003314
• CAS Number: 35899-54-8
• Molecular Formula: C14H21N5O3S
• Molecular Weight: 339.41
• Purity: ≥95%
• Target: spermine synthase
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IC50: 8 uM
• IUPAC Name: (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(2-methylpropylsulfanylmethyl)oxolane-3,4-diol
• InChI: InChI=1S/C14H21N5O3S/c1-7(2)3-23-4-8-10(20)11(21)14(22-8)19-6-18-9-12(15)16-5-17-13(9)19/h5-8,10-11,14,20-21H,3-4H2,1-2H3,(H2,15,16,17)/t8-,10-,11-,14-/m1/s1
• InChIKey: JDDUQGRUPLKDNT-IDTAVKCVSA-N
• SMILES: CC(C)CSCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

SIBA（Cat No.:I003314）, or 5′-Isobutylthioadenosine, is a synthetic analogue of S-adenosylhomocysteine (SAH). It functions as an inhibitor of SAH-mediated transmethylation. SIBA has the ability to interfere with the activities of several enzymes in vitro, including SAH hydrolase, methylthioadenosine phosphorylase, and cAMP phosphodiesterase. It exhibits reversible inhibition of the proliferation of herpes simplex virus (HSV) type 1. These properties make SIBA a valuable compound for studying transmethylation processes and exploring potential antiviral therapeutic applications targeting HSV-1.

Reference

[1]. Carteni-Farina M, et al. Studies on the metabolism of 5/’-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270.
[2]. Lawrence F, et al. Effect of 5/’-deoxy-5/’-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.