For research use only. Not for therapeutic Use.
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].
SIC5-6 (30 μM, 100 μM) increases the activity of Caspase-1 and Rad21 cleavage dose-dependently in HeLa cells. (Rad21: containing the Separase cleavage site conjugated to the fluorescent dye Rh110 (HY-D0817))[1]
| Catalog Number | I041791 |
| CAS Number | 2410846-16-9 |
| Synonyms | 3-[4-(1H-indol-3-yl)-1-(4-iodophenyl)sulfonylpiperidin-4-yl]-1H-indole |
| Molecular Formula | C27H24IN3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C27H24IN3O2S/c28-19-9-11-20(12-10-19)34(32,33)31-15-13-27(14-16-31,23-17-29-25-7-3-1-5-21(23)25)24-18-30-26-8-4-2-6-22(24)26/h1-12,17-18,29-30H,13-16H2 |
| InChIKey | JRVKJWXBSOQUOI-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1(C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54)S(=O)(=O)C6=CC=C(C=C6)I |
| Reference | [1]. Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14(10):2155-2159. |
