For research use only. Not for therapeutic Use.
SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].
SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].
| Catalog Number | R024463 |
| CAS Number | 868224-75-3 |
| Synonyms | ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate |
| Molecular Formula | C24H24N2O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H24N2O7/c1-3-30-24(29)15(2)33-19-6-4-5-18-17(19)9-10-26(23(18)28)13-22(27)25-12-16-7-8-20-21(11-16)32-14-31-20/h4-11,15H,3,12-14H2,1-2H3,(H,25,27) |
| InChIKey | NFBXJAYFPJYHPU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C(C)OC1=CC=CC2=C1C=CN(C2=O)CC(=O)NCC3=CC4=C(C=C3)OCO4 |
| Reference | [1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784. [2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23. |
