Sildenafil-d3

• CAT Number: S000301
• CAS Number: 1126745-90-1
• Molecular Formula: C22H27D3N6O4S
• Molecular Weight: 477.59
• Purity: ≥95%
• Target: Phosphodiesterase (PDE)
• IUPAC Name: 5-[2-ethoxy-5-[4-(trideuteriomethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
• InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)/i3D3
• InChIKey: BNRNXUUZRGQAQC-HPRDVNIFSA-N
• SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

Sildenafil-d3（Cat No.:S000301） is a deuterated version of sildenafil, where three hydrogen atoms are replaced with deuterium, enhancing its molecular stability. This modification makes it especially valuable as an internal standard for precise analytical methods such as mass spectrometry and NMR spectroscopy. Sildenafil is widely known for treating erectile dysfunction and pulmonary arterial hypertension by inhibiting phosphodiesterase type 5 (PDE5), which increases blood flow. The use of sildenafil-d3 allows for more accurate pharmacokinetic and metabolic studies, helping researchers to better understand the drug’s behavior in biological systems.