Sildenafil-d8

• CAT Number: S000302
• CAS Number: 951385-68-5
• Molecular Formula: C22H22D8N6O4S
• Molecular Weight: 482.63
• Purity: ≥95%
• IUPAC Name: 5-[2-ethoxy-5-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
• InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)/i10D2,11D2,12D2,13D2
• InChIKey: BNRNXUUZRGQAQC-BGKXKQMNSA-N
• SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

Sildenafil-d8（Cat No.:S000302） is a deuterated form of sildenafil, where eight hydrogen atoms are replaced with deuterium, significantly enhancing its molecular stability. This attribute makes it a valuable internal standard for advanced analytical techniques such as mass spectrometry and NMR spectroscopy. Sildenafil is primarily known for treating erectile dysfunction and pulmonary arterial hypertension by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which promotes increased blood flow. Utilizing sildenafil-d8 in research allows for more accurate and detailed pharmacokinetic and metabolic studies, aiding in the understanding of sildenafil’s interactions and behavior within biological systems.