For research use only. Not for therapeutic Use.
Silibinin (CAT: I002745) is a natural flavonoid compound derived from milk thistle seeds (Silybum marianum). It exhibits hepatoprotective effects and is commonly used as a dietary supplement. Silibinin has antioxidant, anti-inflammatory, and anti-fibrotic activities, making it useful for protecting the liver against damage from toxins, drugs, and alcohol. It also shows potential as an anticancer agent, inhibiting tumor growth and inducing cancer cell apoptosis. Silibinin has been investigated for its therapeutic applications in liver disorders, cancer, diabetes, neurodegenerative diseases, and skin disorders.
| Catalog Number | I002745 |
| CAS Number | 22888-70-6 |
| Synonyms | Silibinin A;Silymarin I |
| Molecular Formula | C25H22O10 |
| Purity | ≥95% |
| Target | anticancer |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | 3 years -20C powder |
| InChIKey | SEBFKMXJBCUCAI-HKTJVKLFSA-N |
| Reference | </br>1:Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. Yazdi Rouholamini SE, Moghassemi S, Maharat Z, Hakamivala A, Kashanian S, Omidfar K.Artif Cells Nanomed Biotechnol. 2017 May 16:1-12. doi: 10.1080/21691401.2017.1326928. [Epub ahead of print] PMID: 28509572 </br>2:Therapeutic effects of silibinin on LPS-induced acute lung injury by inhibiting NLRP3 and NF-κB signaling pathways. Tian L, Li W, Wang T.Microb Pathog. 2017 May 5;108:104-108. doi: 10.1016/j.micpath.2017.05.011. [Epub ahead of print] PMID: 28483599 </br>3:Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide. Gülden M, Appel D, Syska M, Uecker S, Wages F, Seibert H.Food Chem Toxicol. 2017 Apr 27;105:486-497. doi: 10.1016/j.fct.2017.04.035. [Epub ahead of print] PMID: 28458011 </br>4:Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells. Byun HJ, Darvin P, Kang DY, Sp N, Joung YH, Park JH, Kim SJ, Yang YM.Oncol Rep. 2017 Apr 19. doi: 10.3892/or.2017.5588. [Epub ahead of print] PMID: 28440514 </br>5:Silibinin Improves TNF-α and M30 Expression and Histological Parameters in Rat Kidneys After Hepatic Ischemia/Reperfusion. Kyriakopoulos G, Tsaroucha AK, Valsami G, Lambropoulou M, Kostomitsopoulos N, Christodoulou E, Kakazanis Z, Anagnostopoulos C, Tsalikidis C, Simopoulos CE.J Invest Surg. 2017 Apr 18:1-9. doi: 10.1080/08941939.2017.1308044. [Epub ahead of print] PMID: 28418711 </br>6:Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade. Choi ES, Oh S, Jang B, Yu HJ, Shin JA, Cho NP, Yang IH, Won DH, Kwon HJ, Hong SD, Cho SD.Cell Oncol (Dordr). 2017 Apr 11. doi: 10.1007/s13402-017-0318-8. [Epub ahead of print] PMID: 28401485 </br>7:Silibinin treatment prevents endotoxin-induced uveitis in rats in vivo and in vitro. Chen CL, Chen JT, Liang CM, Tai MC, Lu DW, Chen YH.PLoS One. 2017 Apr 4;12(4):e0174971. doi: 10.1371/journal.pone.0174971. eCollection 2017. PMID: 28376126 Free PMC Article</br>8:Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatory effects on skin damage UVB radiation-induced in mice. Marchiori MC, Rigon C, Camponogara C, Oliveira SM, Cruz L.J Photochem Photobiol B. 2017 Mar 23;170:25-32. doi: 10.1016/j.jphotobiol.2017.03.015. [Epub ahead of print] PMID: 28365493 </br>9:Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Jahanafrooz Z, Motamed N, Bakhshandeh B.Cytotechnology. 2017 Mar 20. doi: 10.1007/s10616-017-0076-5. [Epub ahead of print] PMID: 28321778 </br>10:The protective effects of silibinin in the treatment of streptozotocin-induced diabetic osteoporosis in rats. Wang T, Cai L, Wang Y, Wang Q, Lu D, Chen H, Ying X.Biomed Pharmacother. 2017 May;89:681-688. doi: 10.1016/j.biopha.2017.02.018. Epub 2017 Mar 6. PMID: 28273632 |
