For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Sinapine, an alkaloid derived from seeds of the cruciferous species, possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression.<br>In vitro: sinapine plays an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. [1] sinapine can effectively protect against ·OH-induced damage to DNA and MSCs. [2] Sinapine promotes doxorubicin accumulation in Caco-2 cell by inducing P-gp decrease. Sinapine significantly reduces phosphorylation of FRS2α, ERK1/2. Sinapine sensitive effects may occur through the suppression FGFR4-FRS2α-ERK1/2 signal pathway. [3]</p>
| Catalog Number | I004759 |
| CAS Number | 7431-77-8 |
| Molecular Formula | C17H24N2O5S |
| Purity | ≥95% |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| Reference | <p style=/line-height:25px/> <br>[2]. Li X et al. Protective Effect of Sinapine against Hydroxyl Radical-Induced Damage to Mesenchymal Stem Cells and Possible Mechanisms. Chem Pharm Bull (Tokyo). 2016;64(4):319-25. <br>[3]. Guo Y et al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. </p> |
