Sineptina

• CAT Number: M049374
• CAS Number: 1392-21-8
• Molecular Formula: C35H59NO13
• Molecular Weight: 701.84
• Purity: ≥95%
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: 2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• InChI: InChI=1S/C35H59NO13/c1-19-16-23(14-15-37)31(32(44-8)25(39)17-26(40)45-20(2)12-10-9-11-13-24(19)38)49-34-29(41)28(36(6)7)30(21(3)47-34)48-27-18-35(5,43)33(42)22(4)46-27/h9-11,13,15,19-25,27-34,38-39,41-43H,12,14,16-18H2,1-8H3/b10-9+,13-11+/t19-,20-,21-,22+,23+,24+,25-,27+,28-,29-,30-,31+,32+,33+,34+,35-/m1/s1
• InChIKey: XYJOGTQLTFNMQG-KJHBSLKPSA-N
• SMILES: C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)O

Sineptina（Cat No.:M049374）is a potent, selective inhibitor of serotonin and norepinephrine reuptake, primarily used as an antidepressant. It works by enhancing the levels of these neurotransmitters in the synaptic cleft, which is believed to alleviate mood disorders. Sineptina is commonly prescribed for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). Its efficacy has been supported by clinical studies, showing improvements in both mood regulation and anxiety reduction. It is typically administered orally and is known for its favorable side-effect profile compared to other similar drugs.

Reference

Leucomycin, a new antibiotic. Hata T. et al. J. Antibiotics Ser. A 1953, 6, 87.The chemistry of leucomycins. VI. Structures of leucomycin A4, A5, A6, A7, A8 and A9. Omura S. et al. J. Antibiot. 1968, 21, 272.Structure-biological activities relationships among leucomycins and their derivatives. Mura S. et al. J. Antibiot. 1968, 21, 532.