Sinomenine N-oxide

• CAT Number: I041183
• CAS Number: 1000026-77-6
• Molecular Formula: C19H23NO5
• Molecular Weight: 345.39
• Purity: ≥95%
• Synonyms: (1R,9S,10S)-3-hydroxy-4,12-dimethoxy-17-methyl-17-oxido-17-azoniatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one
• IUPAC Name: (1R,9S,10R)-3-hydroxy-4,12-dimethoxy-17-methyl-17-oxido-17-azoniatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one
• InChI: InChI=1S/C19H23NO5/c1-20(23)7-6-19-10-14(21)16(25-3)9-12(19)13(20)8-11-4-5-15(24-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13-,19+,20?/m0/s1
• InChIKey: IQCNMIIBBLJCAC-XMPQHNGSSA-N
• SMILES: C[N+]1(CC[C@@]23CC(=O)C(=C[C@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC)[O-]

Sinomenine N-oxide（Cat No.:I041183）is a derivative of sinomenine, a natural alkaloid isolated from the plant Sinomenium acutum, known for its anti-inflammatory and immunosuppressive properties. Sinomenine N-oxide has shown potential in preclinical studies for treating autoimmune diseases, such as rheumatoid arthritis, by modulating immune cell activity and reducing inflammation. It is believed to act through the inhibition of pro-inflammatory pathways and cytokine production. Research is ongoing to further understand its mechanism of action, safety, and efficacy, with the goal of developing it as a therapeutic agent for chronic inflammatory conditions.